With the newly released COVID-19 vaccines comes the promise of an eventual return to a more normal workplace and way of life. But there’s no playbook for the vaccine roll-out and, as with the pandemic response itself, employers have an important role to play in this national effort. While some employers are exploring whether to mandate vaccination or even to provide or facilitate access, all employers should be thinking about a communications strategy to provide guidance and support to employees at this critical juncture. Whatever approach you take or position you adopt toward COVID-19 vaccinations, a thoughtful and empathetic communication plan can be the difference between confusion or resistance and understanding and adoption. This article offers some guiding principles to consider.